Sai-Hong Ignatius Ou, MD, PhD

Professor Ou is board-certified in Internal Medicine (2020 renewal) and Medical Oncology (2023 renewal) by the American Board of Internal Medicine, and a Hamoui Salous Endowed Chair in Thoracic Oncology Research.

He has published more than 180 peer-reviewed manuscripts (including New England Journal of Medicine, Lancet Oncology, Journal of Clinical Oncology, Cancer Discovery, Nature Medicine) primarily in the field in targeted therapy including resistance mechanisms to targeted therapy in lung cancer.

In particular, Professor Ou is one of the seven original principal investigators for the still ongoing phase I crizotinib trial that has led to the approval of crizotinib for the treatment of anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) and ROS1-rearranged NSCLC which is now currently investigating the activity of crizotinib in MET exon 14 altered NSCLC. Other clinical research that Professor Ou has involved in has led to the approval of afatinib in uncommon EGFR mutations, Alectinib and Lorlatinib for ALK TKI-refractory ALK+ NSCLC.

Currently first-in-human phase 1 trials that Professor Ou are conducting includes a 3G ROS1/2G NTRK TKI (Repotrecitnib), a next generation RET inhibitor (BlU667), RMC-4630 (SHP2 inhibitor) as a single agent or in combination, and MRTX849 (direct covalent allosteric KRAS G12C inhibitor). The newest target Professor Ou is involved in is targeting NRG1+ fusion malignancies. Professor Ou also actively collaborate with commercial sequencing companies to mine their database to investigate their database on resistance mechanisms and treatment outcome to targeted therapy and also identification of extremely rare actionable driver mutations.

Professor Ou is the editor-in-chief of Lung Cancer: Targets and Therapy and Associate editor of Journal of Thoracic Oncology, editorial board member for Annals of Oncology, Critical Reviews in Oncology/Hematology, Clinical Lung Cancer, and Translational Lung Cancer Research. He is a member of the scientific program committee for metastatic non-small lung cancer track for the American Society of Clinical Oncology (ASCO) (2016-2018).

Other Related Resources
Scientific Advisory Committee